CRG Symposium 20147th November, 2014. Second day of the 13th CRG Symposium
Friday, November 7, 2014
The second and last day of this CRG Symposium was focused on Cell Reprogramming, Aging and Cancer. Many results were shown on the link between Senescence and Cancer….
“Dynamic Expression of the de novo DNA Methyltransferases DNMT3A and DNMT3B during epidermal stem cells differentiation”. Lorenzo Rinaldi
Friday, November 7, 2014
The epidermis is a multi-layered structure in which epigenetic factors are differentially expressed. The investigation of this dynamic expression using an in vitro differentiation system reveals a strong…
“Reprogramming in vivo and its impact on tissue homeostasis and regeneration”. Manuel Serrano
Friday, November 7, 2014
Despite the high interest in the reprogramming field due to the potential therapeutical applications, the possibility to change the cellular identity in vivo within the tissues will represent…
“Direct lineage reprogramming towards the neural lineage”. Marius Wernig
Friday, November 7, 2014
Marius Wernig is the scientist who first directly converted fibroblast into Induced Neurons (iN) with the ectopic expression of only three factors. In this talk, he argumented that…
“Investigating a novel role for senescence-associated stem cell gene expression”. Mekayla Storer
Friday, November 7, 2014
During senescence, cells undergo a proliferative arrest that seems to induce a tumorigenic effect on the neighbouring cells through secretion of specific molecules. The identification of senescence-related genes…
“Pluripotent stem cells: capture of the ground state”. Austin Smith
Friday, November 7, 2014
Austin Smith is probably the investigator that is constantly giving more indications on how to capture the ground state of pluripotent stem cells. His work is based on…
“Cancer drivers and Dependencies”. Scott Lowe
Friday, November 7, 2014
The path of cancer evolution dictates the tumor response to therapy and creates unique vulnerabilities that represent therapeutic opportunities. Based on this concept, Lowe’s Lab is developing powerful…
“Long-range regulation during development and evolution”. Denis Duboule
Friday, November 7, 2014
The formation of digits during development is a high regulated process coordinates by the Hoxd genes. By analyzing the chromosome conformation and Hox transcriptional regulation during the process,…
“Mature hepatocytes are source of bipotential oval cells in chronic liver injury”. Markus Grompe
Friday, November 7, 2014
The liver is an organ with a high regeneration potential and Markus Grompe is one of the most excellent scientists working in this field. Using lineage tracing mice,…
“Mechanisms for programming cell fate”. Kenneth Zaret
Friday, November 7, 2014
The concept that it is possible to reprogram the cell fate for therapeutic purpose is one of the hottest field of the last years. Kenneth Zaret is investigating…
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