Cellular senescence is defined as a basic aging process characterized by an irreversible growth arrest and a multi-faceted secretory phenotype (SAPS). Senescent cells have potent paracrine activities on…
The first day of the 13th CRG Symposium was focused on Chromatin Architecture & Dynamics and on the Mechanisms of Gene Regulation. The talks of some of the…
It is known that over expression of one single transcription factor, C/EBPa, is sufficient to convert B cells into macrophages thus regulating the transdifferentiation towards different lineages. However,…
AU-rich elements (AREs) are known to regulate the mRNA stability and about the 16% of human mRNAs contain this element. The sequence is recognized by specific ARE binding…
RNA binding proteins are multifunctional factors that have a key role in the regulation of gene expression. Among them, Upstream of N-Ras (UNR) seems to be involved in…
Using various ligation reactions, the Rajewsky’s lab identified thousands of miRNA-target interactions in vivo providing new insights in the specificity of miRNA target recognition. Moreover, they identified a…
Mutations in human CEP63 centrosome protein cause Seckel syndrome, characterized by growth retardation and microencephaly. In mice deficient for CEP63, which recapitulate the human pathology, cell death seems…
Intron retention (IR) is the least well understood class of alternative splicing (AS) of precursor RNAs. Despite it represents the least prevalent form of AS in animals, it…
In order to replicate DNA or to regulate gene expression, cells need a lot of energy, but how it is produced so fast in response to specific stimuli…
Cramer’s work aims to elucidate the mechanisms of genome transcription and its regulation in eukaryotic cells. Using structural biology methods and functional genomics, Cramer characterized the Pol II-mediator…
CRG Symposium 2014