“Regulatory RNAs”. Nikolaus Rajewsky

Using various ligation reactions, the Rajewsky’s lab identified thousands of miRNA-target interactions in vivo providing new insights in the specificity of miRNA target recognition. Moreover, they identified a novel lincRNA that is bound but not processed by Dicer, acting as a “Dicer sponge” in C.elegans. A part of its work is also focused on the elucidation of the function of circular RNAs that are not detected as linear molecules and that are also expressed in the brain.

Published data on circRNAs are annotated in www.circbase.org