“Stem cells, cancer and aging: the cellular senescence connection”. Judith Campisi

Cellular senescence is defined as a basic aging process characterized by an irreversible growth arrest and a multi-faceted secretory phenotype (SAPS). Senescent cells have potent paracrine activities on normal and premalignant cells often inducing malignant phenotypes. Studying the behavior of senescent cells in vivo Judith Campisi showed that The SAPS can create a pro-inflammatory tissue environment that stimulates the development of cancer metastases. Thus, a better knowledge of the component of the SAPS could be beneficial to combat aging phenotypes and pathologies correlated with senescence.