During senescence, cells undergo a proliferative arrest that seems to induce a tumorigenic effect on the neighbouring cells through secretion of specific molecules. The identification of senescence-related genes…
The path of cancer evolution dictates the tumor response to therapy and creates unique vulnerabilities that represent therapeutic opportunities. Based on this concept, Lowe’s Lab is developing powerful…
Cellular senescence is defined as a basic aging process characterized by an irreversible growth arrest and a multi-faceted secretory phenotype (SAPS). Senescent cells have potent paracrine activities on…
RNA binding proteins are multifunctional factors that have a key role in the regulation of gene expression. Among them, Upstream of N-Ras (UNR) seems to be involved in…
CRG Symposium 2014