The formation of digits during development is a high regulated process coordinates by the Hoxd genes. By analyzing the chromosome conformation and Hox transcriptional regulation during the process,…
The concept that it is possible to reprogram the cell fate for therapeutic purpose is one of the hottest field of the last years. Kenneth Zaret is investigating…
It is known that over expression of one single transcription factor, C/EBPa, is sufficient to convert B cells into macrophages thus regulating the transdifferentiation towards different lineages. However,…
AU-rich elements (AREs) are known to regulate the mRNA stability and about the 16% of human mRNAs contain this element. The sequence is recognized by specific ARE binding…
RNA binding proteins are multifunctional factors that have a key role in the regulation of gene expression. Among them, Upstream of N-Ras (UNR) seems to be involved in…
Intron retention (IR) is the least well understood class of alternative splicing (AS) of precursor RNAs. Despite it represents the least prevalent form of AS in animals, it…
Kinases are known to regulate gene expression influencing transcription factors and co-regulators; however, recently it is emerging a new role of these enzymes also in the dynamic of…
If we compare the size of the complexes that architectural proteins form on the genome, we could define high occupied regions that are enriched at borders of topologically…
Despite the post-translational modification of proteins are mainly considered uncontrolled phenomenon, active enzymes regulate phosphorylation, methylation and oxidation of proteins. Important oxidation processes seem to be crucial for…
How do cells regulate gene transcription upon a stress? At the Cornell University, Jhon Lis is trying to answer to this question. Using the heat shock response model…
CRG Symposium 2014