“The role of architectural proteins in the three-dimensional organization of the chromatin”. Victor Corces

If we compare the size of the complexes that architectural proteins form on the genome, we could define high occupied regions that are enriched at borders of topologically associating domains (TADs). During an heat shock, many genes are down regulated and only few response genes are activated suggesting that a dramatic reorganization of the chromosomal structure has to be activated as well as the alteration of the localization of architectural proteins. Thus, cells should possess a still unknown mechanisms to regulate the localization of these proteins and the three-dimensional arrangement of the genome. Victor Corces studies provide new insights in the protein modifications that could regulate the role of insulators and of architectural proteins in the dynamic change of the genome three-dimensional structure.

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