“Oncogenes properties of the RNA-binding protein UNR: targets in melanoma”. Laurence Wurth

RNA binding proteins are multifunctional factors that have a key role in the regulation of gene expression. Among them, Upstream of N-Ras (UNR) seems to be involved in mRNA regulation at the levels of translation and stability. In a tumor context, depletion of UNR modifies cancer specifics properties as growth and clonogenicity of melanoma cells. On the other hand, its over expression in primary cell cultures induces transformation. Even if many RNA targets were identified, its function is still under investigation in Fatima Gebauer’s lab.